Hijacking of host metabolic machinery by viral proteins and host genomic reprogramming by viral RNA, is critical for viral biogenesis and propagation. During the pathogenesis, SARS-CoV-2 reprograms and dysregulates several host cellular pathways that involve metabolism, bioenergetics, iron-redox signaling, and immunity – collectively termed as viral-induced HMR/D. Pathophysiological manifestations of HMR/D in acute onset of COVID-19 and during chronic persistence of PASC is a cumulative outcome of metabolic remodeling culminating from both viral-induced cellular damage as well as antiviral host responses. Extensive clinical data combined with genomic/metabolomic profiles has revealed several acute and chronic physio-chemical vulnerabilities both among SARS-CoV-2 infected COVID-19 cases as well as virus-free (RT-PCR negative) PASC patients. SARS-CoV-2-induced HMR/D triggers viral pathogenesis by re-directing free amino acids and fatty acids from host cellular metabolism, as vital building blocks to support viral progeny and propagation. Therefore, precision nutrition to ‘reset’ (or resolve) viral-induced HMR/D is a functional strategy to combat both COVID-19 and PASC. An ideal nutritional remedy should demonstrate human randomized clinical trial (RCT)-proven health benefits with optimal Administration, Distribution, Metabolism, Excretion (ADME) profile and functional efficacy to reset HMR/D and facilitate total recovery of PASC patients. Accordingly, such precision nutrition protocols consisting of specific bio-functional compounds to reset or resolve viral-induced HMR/D are listed below: